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Barbiturate Intoxication and Overdose: Clinical Pharmacology, Toxicity Management, and Global Regulatory Frameworks
The clinical study and management of central nervous system depressants remain cornerstone topics within emergency medicine, clinical toxicology, and international public health. Among these agents, barbiturates occupy a historic and heavily scrutinized position. Once widely prescribed for anxiety, insomnia, and seizure disorders, their narrow therapeutic index and high potential for abuse have led to strict…